| Lesson | Topic | Statement(s) and Objective(s) | Activities |
| 1 | Amino Acids | 2.1.S1: Drawing molecular diagrams of glucose, ribose, a saturated fatty acid and a generalized amino acid.
2.4.U2: There are 20 different amino acids in polypeptides synthesized on ribosomes.
2.4.NOS: Looking for patterns, trends, and discrepancies- most but not all organisms assemble proteins from the same amino acids.
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Amino acids properties handwritten A&B: Evolutionary History of Amino Acids |
| 2 | Essential Amino Acids | D.1.U4: Some fatty acids and some amino acids are essential.
D.1.U1: Essential nutrients cannot be synthesized by the body, therefore they have to be included in the diet.
D.1.U5: Lack of essential amino acids affects the production of proteins.
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| 3 | Protein Folding | 7.3.U7: The sequence and number of amino acids in the polypeptide is the primary structure.
2.4.U4: The amino acid sequence of polypeptides is coded for by genes.
2.4.U1: Amino acids are linked together by condensation to form polypeptides.
2.4.S1: Drawing molecular diagrams to show the formation of a peptide bond.
2.4.U3: Amino Acids can be linked together in any sequence giving a huge range of possible polypeptides.
7.3.U8: The secondary structure is the formation of alpha helices and beta pleated sheets stabilized by hydrogen bonding
7.3.U9: The tertiary structure is the further folding of the polypeptide stabilized by interactions between R groups.
2.4.U6: The amino acid sequence determines the three-dimensional conformation of a protein.
2.4.U5: A protein may consist of a single polypeptide or more than one polypeptide linked together.
7.3.10: The quaternary structure exists in proteins with more than one polypeptide chain (may also involve the binding of a prosthetic group to form a conjugated protein).
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Protein folding dance and example Handwritten protein folding notes Handwritten protein folding review Scitable: protein structure Proteins - Pathway - LabXchange Reading: 3D structure of protein Reading: Alzheimer’s prion Reading: mystery of protein folding Reading: proteins and proteomics Reading: seeds of dementia Reading: when good proteins go bad Reading: seeds of dementia Scitable: the protein data bank Sctable: protein folding and disease Amino acid side chains for toobers Modeling protein folding with paper amino acids Protein molecular visualization Huntington's spreads like 'fire in the brain.' Scientists say they've found the spark Course Source - CoV Spike Protein Visualization Course Source - Gluten Protein A&B: Biochemistry: Peptide 'fingerprint' enables earlier diagnosis of Alzheimer's disease A&B: ‘The entire protein universe’: AI predicts shape of nearly every known protein |
| 4 | Denaturation |
Eggsperiment Data Collection Form A&B: renaturing egg proteins |
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| 5 | Protein Functions | 2.4.U8: Every individual has a unique proteome .
2.4.U7: Living organisms synthesize many different proteins with a wide range of functions.
2.4.A1: Rubisco, insulin, immunoglobulins, rhodopsin, collagen and spider silk as examples of the range of protein functions.
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Classes of proteins handwritten notes Scitable: protein function Protein structure/function jigsaw slides Protein structure/function sorting cards Protein structure/function Jamboard sort A&B: Proteins rule (questions) A&B: tangled protein web A&B: Spider Silk Is Stronger Than Steel. It Also Assembles Itself. |
| 6 | Wrap Up and Review |
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